When it was deemed necessary to release Mariko in order to terminate Lucy, Saito was present to greet Mariko as she exited her tank. The emaciated Mariko hobbled over to Saito and asked if she was her "mommy". Saito replied yes, but Mariko giggled and said "No you're not." She then tore Saito in half and threw her torso through the window of the control booth on the other side of the room. Saito actually managed to survive long enough to activate a control on the console to set off one of several micro-explosives implanted in Mariko's body, pacifying her. Saito then succumbed to her massive trauma and died.