Fulton Balcus is loosely based on Dr. Hamilcar Barcas, a major antagonist of the Japanese Guyver comic and anime series. The difference in characters is quite significant: Fulton is not as old as his manga counterpart and does not appear to possess nearly the level of psychic ability. However, he does transform into a monstrous Zoalord form, something Dr. Barcas has yet to do in the manga.
When the Guyver Unit is stolen from Chronos' LA branch, Balcus commands his subordinate Lisker to get it back. He becomes enraged when Lisker fails to find the unit and threatens him with his psychic abilities, telling him he will make Lisker slap himself to death if he fails again.
Much later on, Lisker and his gang of Zoanoids kill Sean Barker, host of the Guyver, and kidnap his girlfriend Mizky Segawa and CIA agent Max Reed. Balcus has Reed sent in for Zoanoid optimization and questions Mizky regarding the Guyver. Much to Balcus' shock and amazement, the Guyver's control medal which had been recovered by Lisker regenerates Sean's body. As the Guyver, Sean kills Balcus' mutant flunkies and saves Mizky, but unfortunately Max dies when he is released from his optimization too early.